Hand-foot syndrome is also called palmar-plantar erythrodysesthesia. … Hand-foot syndrome causes redness, swelling, and pain on the palms of the hands and/or the soles of the feet. Sometimes blisters appear. Hand-foot syndrome sometimes happens elsewhere on the skin, such as the knees or elbows.
Read more about what to do about pain in the palm of your hand, when to get help and the common causes.
 This discoloration was noted particularly in the naso-labial folds, on the palms of the hands and the soles of the feet. Carotenemia with its yellowish-red tint is .
The hands and feet are often the first places people notice scleroderma symptoms. Find out more about how they are involved in the condition here.